Diindolylmethane (DIM) is a phytonutrient and plant indole found in cruciferous vegetables, including broccoli, Brussel sprouts, cabbage, cauliflower, and kale, with potential anti-androgenic and anti-neoplastic activities.
DIM provides beneficial estrogen metabolism in both sexes, may reduce the levels of 16-alpha hydroxy estrone metabolites, and may increase the formation of 2-hydroxy estrone metabolites, leading to antioxidant activity and inducing apoptosis in vitro tumor cells.
DIM is unique among all phytonutritionals with regard to its ability to favorably modify estrogen metabolism in the direction of greater 2-hydroxyestrone production.
A wealth of recent studies have documented DIM as one of the most effective phytonutrients in the prophylactic support of breast, prostate, colon, and pancreatic challenges.
DIM is clinically activated in a liposome matrix as it may bypass the “first pass” of the liver and digestive tract directly (ionic ligand), targeting estrogen metabolism.*
Researchers have discovered that the intake of milligram amounts of dietary indoles from cruciferous vegetables can modify the metabolism and growth-promoting activity of estrogen.